Efecto analgésico de citrato de maropitant por goteo continuo en cirugías de ooforo salpingo histerectomía (osh) en caninos

Abstract

The objective of the present investigation was to evaluate the analgesic effect of Maropitant Citrate administered intravenously to continuous trickling in ophoro salpingo surgeries hysterectomy (OSH) in canines. We used 36 female canines from 1 to 3 years of age, ASA I, the design was applied completely randomly with six treatments (experimental doses) and six repetitions. A loading dose of maropitant citrate was administered in the first three treatments at 1 mg / kg by slow IV in the pre-medication, then a continuous drip was performed intraoperatively at a dose of: 0.05 mg / kg / h (T1), 0.1mg / Kg / h (T2) and 0.2mg / Kg / h (T3). In the last three treatments, no loading dose was applied and a continuous drip was administered intraoperatively at a dose of: 0.05mg / kg / h (T4), 0.1mg / kg / h (T5), 0.2mg / kg / h (T6). To determine the control of intraoperative pain, the following physiological constants were evaluated: Heart Rate (HR), Respiratory Frequency (FR), Oxygen Saturation (SPO2), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Blood Pressure Mean (MAP) and the CAM variation of sevoflurane. Through an analysis of variance, the best result obtained was: loading dose (1mg / Kg) + continuous drip dose (0.2mg / Kg / h), in which no significant variations were observed in most somatic markers of pain ; A reduction of CAM was observed to 1.53% of sevoflurane and the decrease in anesthetic risk.