Efecto del ácido hipocloroso como alternativa terapéutica sobre la endometritis bovina posparto.

Abstract

The objective of the present investigation was to Evaluate the effect of hypochlorous acid as a therapeutic alternative on postpartum bovine endometritis, 32 milk producing cows diagnosed with postpartum endometritis were evaluated, through blood analysis, endometrial examination and culture of uterine secretion before and after treatment, these were distributed in four treatments: T1 = 5% oxytetracycline (OTC) intrauterine for 10 minutes, T2 = 5% OTC intrauterine for 15 minutes, T3 = 0.5% hypochlorous acid (HClO) intrauterine for 10 minutes, and T4 = 0.5% HClO intrauterine for 15 minutes, distributed in eight repetitions in each treatment. A completely randomized block design (DBCA) with analysis of variance and Tukey test at 5% was used. The leukogram revealed that the leukocyte values of T4 (9.76 103 / uL) show a better involutional response of inflammation (P <0.0001) in comparison with the rest of treatments (T3 = 10.42 103 / uL, T2 = 16.06 103 / uL, and T1 = 16.45 103 / uL); the neutrophils segmented in T4 (8.23 103 / uL) also showed a better response at the end of the experiment (P <0.0001), compared to the other treatments (T3 = 7.27 103 / uL, T2 = 14.31 103 / uL, and T1 = 15 103 / uL), as regards the neutrophils in band, lymphocytes, eosinophils and monocytes no differences were observed (P = 0 , 0519, P = respectively). Regarding the cytological analysis, it was observed that in all the treatments cataloged as severe processes they are completely eradicated, but treatment 4 stands out for its higher % of cytologist cataloged as a mild process. Regarding the results of the culture for E. coli, T3 and T4 presented better antimicrobial response to the infectious process and with respect to A. pyogenes in all the treatments, a remarkable decrease of bacterial colonies is observed. Given these results, it is inferred that the intra-uterine infusion of hypochlorous acid at 0.5% for 15 minutes, improves the palliative response of the course of the disease, which will result in a shorter uterine involution with better reproductive and productive results.