Browsing by Author "Armijo Soria, Lisbeth Mariela"

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    CISTITIS INTERSTICIAL/SÍNDROME DE VEJIGA DOLOROSA: DIAGNÓSTICO Y TRATAMIENTO FARMACOLÓGICO Y NO FARMACOLÓGICO
    (2025-06-13) Armijo Soria, Lisbeth Mariela; Parra Rosero, Andrea Catalina; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Introduction: Interstitial cystitis (CI/BPS) is a chronic nonbacterial inflammatory disease that causes persistent pain and chronic urinary symptoms, significantly affecting quality of life. The disease has an important psychological component, with high rates of depression and anxiety, which underscores the need to better understand its pathogenic mechanisms and diagnostic methods. Methodology: An updated literature review (2020-2024) was carried out on interstitial cystitis and its diagnosis and treatment. We consulted 35 sources, including metaanalyses, systematic reviews, and clinical trials. The databases used were Google Scholar, PubMed, The New England, ELSEVIER, Wiley Online Library and Dialnet, using key terms in English. Studies prior to 2020, duplicate information or information not relevant to the objectives were excluded. Results: Urinary biomarkers are emerging as promising diagnostic tools, although they still need clinical validation. Cystoscopy remains a key tool for the identification of specific lesions, such as Hunner's ulcers, but its sensitivity is limited. In terms of treatment, pharmacological therapies (pentosan polysulfate sodium and amitriptyline) stand out, which have shown mixed results and side effects. Intravesical treatments, such as dimethyl sulfoxide (DMSO) and glycosaminoglycan therapy, have also shown limited efficacy. Discussion: Interstitial cystitis remains a complex disease, and its management is challenging due to the lack of definitive treatments and the side effects of current therapies. Pharmacological options are not always effective, and intravesical treatments require invasive procedures. Conclusions: The diagnosis of HF/BPS remains complicated due to the lack of specific markers. Non-pharmacological therapies, such as diet modification and stress management, are essential and can complement pharmacological treatments, improving patients' quality of life.