Browsing by Author "Castillo Mayorga Alejandra Monserrath"

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    DENERVACIÓN SIMPÁTICA RENAL UNA ALTERNATIVA TERAPÉUTICA EN PACIENTES CON HIPERTENSIÓN ARTERIAL REFRACTARIA
    (2025-06-18) Castillo Mayorga Alejandra Monserrath; Andrade Albán Noemí Rocio; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Refractory arterial hypertension (HRT) is characterized by the inability to control blood pressure, which exceeds 140/90 mmHg, despite the use of five or more antihypertensive drugs of different classes, including a long-acting thiazide diuretic and a mineralocorticoid receptor antagonist, at maximum or tolerated doses. Although renal denervation (RDN) has shown potential to reduce blood pressure, its efficacy and safety are still debated, which is why a systematic review was proposed to evaluate the results and effectiveness of RDN in patients with HTN. A descriptive and systematic approach based on the PRISMA guidelines was used, reviewing literature in PubMed, Embase, Cochrane Library and Scopus, with terms MeSH and DECs, and limiting the search to articles in English or Spanish published in the last five years. Those that do not focus on the topic or different from the language indicated were excluded, resulting in 15 articles for review. The results and conclusion indicate that RDN has shown a significant reduction in systolic and diastolic blood pressure in some cases, with decreases of between 5 mmHg and 32 mmHg. However, the results are inconsistent: some studies report modest or no reductions compared to sham treatments or standard controls; and, improvements in blood pressure are usually more evident in the short term, but the long-term efficacy and effects on cardiovascular events and kidney function still require more research.