Browsing by Author "Ortega Becerra Andrea Nathalia"

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    PERFIL GENÓMICO DEL CÁNCER DE CUELLO UTERINO EN EL DIAGNÓSTICO DE VPH
    (2025-02-25) Ortega Becerra Andrea Nathalia; Valenzuela Sánchez Gabriela Paola; Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico
    Cervical cancer is a disease characterized by cellular abnormalities, typically caused by the presence of the human papillomavirus (HPV), specifically high-risk genotypes such as HPV-16 and HPV-18. However, there are subtypes of cervical cancer that are not associated with the virus, and it is linked to external factors. The objetive was analyze the genomic profile of cervical cancer through bibliography review. The majority of genes and proteins were found to be mutated or overexpressed due to the activity of the E6 and E7 HPV oncoproteins. However, in HPV-unassociated cervical cancers, these genetical markers are altered as a result of mutations or loss of functions that could influence them directly or impact the signaling pathways. In conclusion, the implementation of these biomarkers could facilitate early diagnosis and personalized treatment of different subtypes of cervical cancer, particularly those are not associated with the human papillomavirus.