Browsing by Author "Pico Sánchez, Dayana Fernanda"

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    DE LA MICROSCOPÍA A LA SECUENCIACIÓN GENÉTICA: LA EVOLUCIÓN EN LAS TÉCNICAS DE DIAGNÓSTICO DE LA LEUCEMIA LINFOIDE AGUDA
    (2025-02-25) Pico Sánchez, Dayana Fernanda; Rosero Freire, Daniela Alexandra; Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico
    Acute Lymphoblastic Leukemia (ALL) is a highly heterogeneous hematological disease that affects both children and adults, with cure rates that have increased over the years. This progress is attributed to advancements in diagnostic techniques, which have contributed to earlier and more precise detection, monitoring of ALL progression, and prognosis assessment. The objective of this article is to provide a comprehensive and updated review of the advances in techniques used for diagnosing ALL. It was found that diagnosis begins with results obtained from conventional techniques, such as complete blood count and cellular morphology analysis. However, these must be complemented by more advanced techniques, such as karyotyping, FISH, and RT-PCR, which detect molecular-level alterations and mutations. Additionally, other techniques like NGS, although still limited to research laboratories, continue to provide valuable information. These advancements have significantly improved the identification of molecular subtypes and genetic alterations, which are crucial for risk stratification and prognosis. Nonetheless, conventional techniques remain indispensable as the starting point for subsequent analyses.