Browsing by Author "Vásquez Calero, Jonathan Alexander"

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    Desarrollo de formulaciones farmacéuticas microencapsuladas con propiedades antiinflamatorias y antioxidantes a partir de extractos de la planta Muehlenbeckia tamnifolia (Kunth) Meisn
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos. Carrera de Ingeniería Bioquímica, 2018-12) Vásquez Calero, Jonathan Alexander; López Hernández, Orestes Darío
    The present research work was based on the extraction of secondary metabolites of the plant Muehlenbeckia tamnifolia (Kunth) Meisn, flavonoids and total phenols were analyzed and quantified for their anti-inflammatory and antioxidant properties. To take advantage of the properties of the metabolites, two microencapsulated microspheres were developed that contained the extract of Muehlenbeckia tamnifolia (Kunth) Meisn as an active ingredient, using two polymers of the saccharide type maltodextrin and gum arabic. To verify the properties of the microencapsulations, in vitro tests were carried out, the antioxidant activity was determined, which showed a maximum percentage of DPPH inhibition of 74.69 percent equivalent to 400.08 g l-1 of Trolox, the anti-inflammatory capacity was determined by stabilization of the erythrocyte membrane reaching a maximum value of 80.39 percent inhibition of hemolysis and its capacity to inhibit protein denaturation, achieving a maximum percentage of 54.82 percent inhibition of denaturation.