Ciencias de la Salud

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CISTATINA C COMO MARCADOR DE DAÑO RENAL EN PACIENTES CON DIABETES MELLITUS TIPO II
(Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico, 2024-08-13) Gutiérrez Lara, Angela Guadalupe; De la Torre Fiallos, Ana Verónica
Introduction: Type II diabetes is a growing chronic disease, which is associated with the risk of kidney damage, a complication that can lead to kidney failure. Therefore, early detection and monitoring of kidney damage is essential in this type of patient. In this context, cystatin C is a reliable endogenous marker to evaluate kidney function, since its concentration is not influenced by external factors unlike other endogenous markers. Objective: To analyze cystatin C as a marker of kidney damage in patients with type II diabetes mellitus. Methods: An exhaustive investigation was carried out in different databases to identify studies related to the topic of interest. The PRISMA method was used. Results: The studies reviewed demonstrated an association between high cystatin C concentration and a risk of kidney damage in patients with diabetes. In addition , cystatin C suggests being a more sensitive marker than creatinine for detecting kidney problems in early stages. Conclusions: Cystatin C is a promising marker for the evaluation of kidney damage in patients with type II diabetes, due to its sensitivity to detect early changes and determine disease progression.