Ciencias de la Salud

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NUTRIGENÓMICA EN LA PREVENCIÓN DEL CÁNCER
(2025-06-18) Romero Meza Jennifer Nathaly; Cruz Hidalgo Pablo Andrés; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Nutrición y Dietética
Cancer is a disease that represents one of the leading causes of death worldwide and generates an extremely high economic impact on public health systems. However, a considerable number of cancer cases could be prevented through the adoption of appropriate dietary habits and the intake of foods rich in nutrients and bioactive substances. The aim of the present study is to synthesize and evaluate the effects and efficacy of certain bioactive compounds in the prevention of genetic alterations, improvement of the immune system or reduction of systemic inflammation that may lead to cancer. A systematic review was carried out following the PRISMA guidelines, in which studies from the last 5 years found in the Cochrane Library database were included. Considering the inclusion and exclusion criteria, a total of 16 randomized clinical trials were included. Which revealed and support that the incorporation of bioactive compounds present in food, such as polyphenols, carotenoids, glucosinolates, omega- 3 fatty acids, terpenes, phytosterols, lignans and antioxidants has a positive impact on cancer prevention by influencing various molecular mechanisms associated with it.