Ciencias de la Salud

Permanent URI for this communityhttp://repositorio.uta.edu.ec/handle/123456789/813

Browse

Start date: 2020Subject: search.filters.subject.CÁNCER DE CUELLO UTERINO

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    PERFIL GENÓMICO DEL CÁNCER DE CUELLO UTERINO EN EL DIAGNÓSTICO DE VPH
    (2025-02-25) Ortega Becerra Andrea Nathalia; Valenzuela Sánchez Gabriela Paola; Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico
    Cervical cancer is a disease characterized by cellular abnormalities, typically caused by the presence of the human papillomavirus (HPV), specifically high-risk genotypes such as HPV-16 and HPV-18. However, there are subtypes of cervical cancer that are not associated with the virus, and it is linked to external factors. The objetive was analyze the genomic profile of cervical cancer through bibliography review. The majority of genes and proteins were found to be mutated or overexpressed due to the activity of the E6 and E7 HPV oncoproteins. However, in HPV-unassociated cervical cancers, these genetical markers are altered as a result of mutations or loss of functions that could influence them directly or impact the signaling pathways. In conclusion, the implementation of these biomarkers could facilitate early diagnosis and personalized treatment of different subtypes of cervical cancer, particularly those are not associated with the human papillomavirus.
  • No Thumbnail Available
    Item
    ACTUALIZACIÓN DE LA INFECCIÓN POR VIRUS DEL PAPILOMA HUMANO ASOCIADO A CÁNCER DE CUELLO UTERINO CON UN ENFOQUE EN EL DIAGNÓSTICO Y TRATAMIENTO
    (Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Medicina, 2024-06-10) Oña Rodríguez, Tannia Maribel; Silva Acosta, Jissela Del Carmen
    Introduction: Cervical cancer is one of the leading causes of death among women worldwide, and infection with the Human Papillomavirus (HPV) is a significant risk factor for its development. The aim of this review article is to update the knowledge on HPV infection and its association with cervical cancer, with a focus on diagnosis and treatment. Methodology: A systematic review of the literature was conducted using electronic databases such as PubMed, Scopus, and Web of Science. Studies published in English from 2015 to the present that addressed HPV infection and cervical cancer, with a focus on diagnosis and treatment, were included. Results: HPV infection is a significant risk factor for the development of cervical cancer. Diagnostic methods include cervical cytology, HPV testing, and colposcopy. Prevention of cervical cancer can be achieved through HPV vaccination and early detection via screening tests. Conclusions: HPV infection is a significant risk factor for the development of cervical cancer. Diagnostic methods and treatment options are available for the management of HPV infection and cervical cancer. Prevention of cervical cancer can be achieved through HPV vaccination and early detection via screening tests. It is important for healthcare professionals to be up-to-date on the latest recommendations for the prevention and management of cervical cancer.
  • No Thumbnail Available
    Item
    “Actividad pro-apoptótica in vitro del extracto de maranthus hypochondriacus en células cancerígenas”
    (Universidad Técnica de Ambato/Facultad de Ciencias de la Salud/Carrera de Medicina, 2020-07-01) Real Jaramillo, Alex Mateo; Carrero Castillo, Yenddy Nayghit Dra. PhD.
    Introduction: Cancer is a group of pathologies that share an uncontrolled process of growth and division of abnormal cells, which have the ability to spread to any tissue in the human body. The organism is made up of millions of cells that complete a life cycle, that is, they are born, reproduce and die, however, cancer cells lack this property of dying, which causes an increase in tissue, tumors and neoplasms. Cervical cancer is defined as the appearance of abnormal cells in the tissue of the cervix, increasing in size and reproducing without stopping, it is the fourth most common type of cancer in women and in various Latin American countries such as Ecuador, Colombia and Peru It is the cancer that is most frequently detected daily according to the Pan American Health Organization. The Human Papilloma Virus (HPV) together with risk factors such as age over 45 years, start of sexual life under 20 years and several sexual partners is associated in 99% with women who have developed cervical cancer, on the other hand, this virus has an extensive number of subtypes, 15 present a potential danger for developing cancer and specifically, there are 2 subtypes, 16 and 18, that increase the risk. Objective: To evaluate the pro-apoptotic activity in vitro of Amaranthus hypochondriacus extract in cancer cells. Methodology: In the present study, the action and effect of amaranth extract on cancerous cervical cells was investigated, 2 groups of HeLa cells were used, one group added Amaranthus hypochondriacus extract and another group, control without treatment, apoptosis was evaluated in both groups. Results: Bax, Bcl2 and caspase 8 expression was higher in HeLa cells treated with Amaranthus hypochondriacus, while p53 expression was similar in HeLa cells with treatment and without treatment. Conclusion: Amaranthus hypochondriacus in an optimal dose can favor the apoptosis of cancer cells of the cervix. Recommendation: Increase the number of cases that continue with the analysis of the Amaranthus hypochondriacus effect on cancer cells, also carry out a quantitative study which would have great scientific value.