Ciencias de la Salud

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    PERFIL GENÓMICO DEL CÁNCER DE CUELLO UTERINO EN EL DIAGNÓSTICO DE VPH
    (2025-02-25) Ortega Becerra Andrea Nathalia; Valenzuela Sánchez Gabriela Paola; Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico
    Cervical cancer is a disease characterized by cellular abnormalities, typically caused by the presence of the human papillomavirus (HPV), specifically high-risk genotypes such as HPV-16 and HPV-18. However, there are subtypes of cervical cancer that are not associated with the virus, and it is linked to external factors. The objetive was analyze the genomic profile of cervical cancer through bibliography review. The majority of genes and proteins were found to be mutated or overexpressed due to the activity of the E6 and E7 HPV oncoproteins. However, in HPV-unassociated cervical cancers, these genetical markers are altered as a result of mutations or loss of functions that could influence them directly or impact the signaling pathways. In conclusion, the implementation of these biomarkers could facilitate early diagnosis and personalized treatment of different subtypes of cervical cancer, particularly those are not associated with the human papillomavirus.
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    Infección por el virus de papiloma humano (HPV) y displasias de cuello uterino
    (Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico, 2023-03-01) Guzmán Sevilla, Mirka Michelle; Delgado García, María Cecilia
    Worldwide, the Human Papilloma Virus (HPV) has produced a greater number of infections in young women. To establish a cytological diagnosis, it is essential to differentiate the lesions that are precursors of cervical cancer and caused by HPV infection. Richard and Barron, in their studies, demonstrated that there is cytological progress until reaching cancer. This entire process begins with the formation of intraepithelial neoplasia, that is, CIN1, CIN2, CIN3 and carcinoma in situ until the invasive cancer is formed. Material and method: A documentary research was carried out, through a bibliographic review of different scientific articles published on virtual platforms such as Pudmed, Scielo, Elsevier, as well as the classification according to the Bethesda System and the World Health Organization. Discussion: The recent evolution, the Bethesda System, in addition to the evolution of precursor lesions, divides them into low-grade and high-grade lesions demonstrated by cytology and through the Papanicolaou technique and staining. Conclusions: HPV is one of the most common infections caused by sexual transmission. This infection is present in both men and women, and in certain cases it can be asymptomatic, causing a higher incidence rate of infections.