Ciencias de la Salud

Permanent URI for this communityhttp://repositorio.uta.edu.ec/handle/123456789/813

Browse

Filters

20252

Settings

Has files: YesSubject: search.filters.subject.RESTRICCIÓN CALÓRICA

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    DIETAS HIPOCALÓRICAS Y RESISTENCIA A LA INSULINA, POSIBLES BENEFICIOS O COMPLICACIONES
    (2025-06-18) Chasig Quisaguano Adrian Ismael; Bonilla Veloz Silvia Elizabeth; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Nutrición y Dietética
    This article examines the effect of hypocaloric diets on insulin resistance, type 2 diabetes mellitus and metabolic syndrome. Hypocaloric diets are an effective tool to achieve weight loss and improve metabolic health, evidencing positive effects such as increased peripheral insulin sensitivity, decreased liver fat accumulation and lipid profile adequacy. However, if not applied correctly, disadvantages may arise such as decreased muscle mass, alterations at the level of basal metabolism and possible nutritional deficiencies. An analysis of the influence of intermittent fasting and caloric restriction on the regulation of body weight, blood glucose levels and inflammatory markers associated with the cellular aging process is also addressed. Although hypocaloric diets show favorable results in the short term, maintaining adherence to them in the long term remains a challenge, indicating the importance of developing personalized approaches that facilitate their sustainability over time, it has been observed that intermittent diets tend to have greater longterm adherence compared to traditional continuous diets, although both are effective in reducing body weight, having greater effectiveness when enhanced with psychological support and the incorporation of physical exercise.
  • No Thumbnail Available
    Item
    RESTRICCIÓN CALÓRICA Y MIMÉTICOS EN EL ENVEJECIMIENTO
    (2025-06-16) Díaz Núñez Kevin Paúl; Cevallos Teneda Andrea Carolina; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Introduction: The aging of the global population has driven the search for strategies to prolong health and delay age-related diseases. Calorie restriction, which reduces caloric intake without malnutrition, is the most studied geroprotective dietary intervention. However, the difficulty of maintaining it has directed research toward drugs that mimic its effects, known as calorie restriction mimetics. Objective: To examine the potential of calorie restriction and its mimetics to delay aging, evaluating their impact on health and longevity, and analyzing their scientific basis and potential therapeutic applications. Methodology: A qualitative literature review based on literature on calorie restriction and its mimetics in relation to aging. Data was compiled from scientific databases such as PubMed, LILACS, and Cochrane, focusing on clinical studies from the last five years. The findings are summarized in a narrative review. Results: Calorie restriction showed significant improvements in health and longevity in experimental and human models, reducing weight, insulin levels, body temperature, and oxidative stress. It promoted autophagy by inhibiting mTOR and activating AMPK. Calorie restriction mimetics, such as metformin and rapamycin, also demonstrated anti-aging effects by modulating nutrient-sensing pathways and reducing oxidative damage, suggesting their potential as alternatives to calorie restriction. Conclusion: Calorie restriction and its mimetics have been shown to promote longevity and muscle quality by activating key metabolic pathways in the aging process. Although they act differently, they promote autophagy and antioxidant protection, suggesting the need for combined approaches to optimize their antiaging effects.