Ciencias de la Salud

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Subject: search.filters.subject.NEURODEGENERACIÓN

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    IMPACTO DE LA MICROBIOTA INTESTINAL COMO DESENCADENANTE DE LA ENFERMEDAD DE PARKINSON
    (2025-06-13) Morales Villacis Karen Alexandra; Padilla Vinueza Verónica Elizabeth; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Years ago, it was believed that the gut microbiota only played a role in the digestion process. Today, it is known that it has a crucial impact on neurological health, to the extent that it has been associated with the development of Parkinson's disease. The objective of this research work is to analyze the role of the microbiota as a trigger for Parkinson's disease. This is a review of the literature related to gut microbiota and Parkinson's disease, which involved the collection and analysis of published bibliography over the last five years in both English and Spanish, yielding significantly relevant conclusions. Recent studies suggest that alterations in microbiota composition influence inflammation and metabolism, contributing factors to the progression of this disease. It is concluded that the bidirectional communication between the gut and the brain, known as the gut-brain axis, underscores the importance of microbiota in modulating the central nervous system, as it initiates systemic inflammatory processes that significantly influence the onset of Parkinson's disease.
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    TERAPIA DE CÉLULAS MADRE EN PACIENTES CON PARKINSON
    (Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Medicina, 2024-09-25) Pérez Cedeño, Jonathan Josué; Marizande Lozada, María Fernanda
    Parkinson's disease (PD) is a chronic neurodegenerative disorder that affects the central nervous system, manifesting through motor symptoms such as tremors, rigidity and bradykinesia. As research advances, stem cell therapies have emerged as a promising strategy for PD, seeking to improve disease severity and restore motor function. A literature review was conducted to examine the current status of stem cell therapy in the treatment of Parkinson's disease, including recent advances in stem cell research, evaluation of challenges and opportunities in its clinical application. . The methodology used focuses on the compilation of previous studies, scientific articles and clinical trials in order to find the most up-to-date and truthful information. The findings demonstrated that stem cell therapies face ethical challenges in obtaining and manipulating cells, especially with embryonic cells, raising questions about the moral status of the embryo. Obtaining adult stem cells raises ethical dilemmas, including informed consent and the possibility of coercion. The surgical complexity varies depending on the cell source and the transplant method, from embryonic cells to reprogrammed somatic cells, using autografts or allografts. Among the complications, adverse immunological reactions, especially in autografts, represent a potential risk. Finally, addressing ethical challenges, refining surgical techniques, and minimizing complications are imperative to solidify stem cell therapies as effective and ethically acceptable treatments for PD. Keyword