Evaluación de tres ciclos en diálisis peritoneal intermitente mediante la medición de nitrógeno ureico sanguíneo (BUN) y creatinina en caninos hiperazotémicos

Abstract

The study evaluated the efficacy of different intermittent peritoneal dialysis cycles (7, 14, and 21) in hyperazotemic canines by measuring blood urea nitrogen (BUN) and serum creatinine levels. Dialysis was performed on 9 dogs aged between 8 and 14 years, including both females and males. Four of them had chronic kidney disease (CKD) stages I and II, while the rest were in stages III and IV according to the IRIS scale. Results showed a significant reduction in BUN (p=0.0001) with increasing cycles, achieving a urea reduction ratio (URR) of 75% with 21 cycles, exceeding 50% with 14 cycles, and reaching 30% with 7 exchanges. Although the creatinine reduction ratio (CRR) was less consistent and not statistically significant (p=0.0795), it showed a tendency to decrease with more cycles. The study concluded that peritoneal dialysis is effective in reducing BUN in canines with chronic renal failure, especially with a higher number of cycles, although it is not recommended in advanced stages (III-IV) of the disease. However, with multiple exchanges, albumin levels should be carefully monitored. The research revealed that, with an increase in the number of IPD cycles, albumin levels decreased significantly in 77.77% of patients, consistent with other studies reporting severe hypoalbuminemia during treatment.