Estudio preliminar de obtención de una nanosuspensión de manguiferina

Abstract

The mangiferine is the main constituent polyphenol leaves, fruits and bark of mango. Its low solubility when isolated, make decrease its absorption, so it is necessary to perform some processing to improve its absorption. The usual methods to improve absorption of this compound include the use of organic solvents which generally cause toxicity or modification the chemical structure of the molecule adding more complexity to processes. In this work it was possible to obtain a suspension of nanometric particles (6,54 nm) using a mixture of ethanol and a surfactant in combination with physical factors such as temperature and mechanical energy, which will contribute to increased absorption by the small size