Browsing by Author "Choez Choez, JonnyJesús"

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    Marcadores bioquímicos de mal pronóstico en pacientes con sepsis
    (Universidad Técnica de Ambato/Facultad de Ciencias de la Salud/Carrera de Laboratorio Clínico, 2023-03-22) Choez Choez, JonnyJesús; Poveda Paredes, Francisco Xavier
    Sepsis is a clinical syndrome characterized by a systemic inflammatory response to an infection in an exacerbated manner, presenting in severe infections such as lactic acidosis, septicemia, septic shock, bacteremia, liver infections, candidiasis, urinary tract infections, neonatal meningitis and gastrointestinal infection, which are caused by bacteria, fungi and viruses, being this the reason to determine the different types of biomarkers that allow to diagnose a bad prognosis due to sepsis, among these we have ferritin, Procalcitonin (PCT), interleukin (IL-6), Lactate dehydrogenase (LDH) and D dimer (DD). A retrospective descriptive observation study was carried out, prioritizing the search for information from different databases such as Scielo, Elsevier, PubMed, which explain biochemical markers that are activated in the face of systemic infectious processes. The choice of various biomarkers for the study of sepsis is based on their sensitivity, specificity and function as in the case of ferritin which is active in both severe and mild inflammatory processes, unlike IL-6 which is activated when a cytosine storm develops, PCT allows differentiating between a septic process from other local or viral infections, DD was implemented because patients with sepsis suffer coagulatory processes although this marker is more used in DIC (disseminated intravascular coagulation). The LDH allows to evaluate the severity of the disease, its response to treatment and prognosis since it causes tissue necrosis in patients. The NEWS scale is implemented in the ICU because it is a parameter that assesses the state of health, allowing the physician to act more quickly. All these parameters remain the most effective means of treating patients with sepsis due to the complexity and accuracy in assessing the patient's current health status.