Browsing by Author "Macías García, Emily Masielle"

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    EVALUACIÓN ANTIMICROBIANA IN VITRO DEL ACEITE ESENCIAL Y MICROENCAPSULADO ROSMARINUS OFFICINALIS FRENTE A BACTERIAS ATCC
    (2025-02-25) Macías García, Emily Masielle; Guangasig Toapanta, Víctor Hernán; Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico
    Bacterial resistance to antibiotics represents a global crisis recognized by organizations such as the WHO, UN, and EU, causing millions of deaths each year (1). In response to this challenge, the search for innovative alternatives to treat resistant infections has become crucial to ensure the effectiveness of treatments. This study focuses on the evaluation of the antimicrobial activity of essential oil (EO) and its microencapsulated form (AEM) derived from Rosmarinus officinalis. Microencapsulation, carried out through spray drying, enhances the stability of the oil, optimizes its efficacy, and enables controlled release, overcoming limitations such as its volatility and reduced effectiveness in its pure form. The antimicrobial properties of EO and AEM were analyzed against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853. AEM demonstrated exceptional performance, with inhibition zones of up to 21.6 mm against S. aureus. Furthermore, minimum inhibitory concentrations (MIC) of 12.5 mg/mL and minimum bactericidal concentrations (MBC) of 25 mg/mL were determined for S. aureus. For E. coli and P. aeruginosa, the MIC values were 25 mg/mL and 50 mg/mL, respectively. These results position AEM as a promising alternative in the healthcare field, standing out for its innovation, effectiveness, and relevance in the context of the growing antimicrobial resistance.