Browsing by Author "Solis Cadena, Dayana Monserrath"

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    REVISIÓN SISTEMÁTICA: ACTUALIZACIÓN DE TERAPIA INTRAARTICULAR EN LAS PATOLOGÍAS TRAUMATOLÓGICAS
    (2025-06-16) Solis Cadena, Dayana Monserrath; Marizande Lozada, María Fernanda; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Introduction: Traumatologic pathologies such as osteoarthritis (OA) affect a large part of the world's population, especially in developing countries, with predisposing factors such as sedentary lifestyle, obesity and trauma. The prevalence of OA increases with age, being more frequent in people over 60 years of age. In Latin America, the prevalence varies, being 7.4% in Ecuador. Short-term treatment aims to relieve pain and improve function, while long-term treatment attempts to slow disease progression. Intra-articular therapies, such as corticosteroids and platelet-rich plasma, are common options, but their long-term effectiveness is uncertain. Objective: The purpose of this paper is to evaluate recent evidence on the effectiveness of intra-articular therapies in the management of traumatologic pathologies. Materials and Methods: A comprehensive search was conducted in databases such as PubMed, Cochrane Library, and Scopus, including studies in English and Spanish published between 2019 and 2024. 21 studies were selected that met criteria such as use of intraarticular therapies (PRP, HA, corticosteroids, combinations). Results: Plateletrich plasma (PRP) is more effective than hyaluronic acid (HA) and corticosteroids in relieving pain and improving joint function in the long term. HA improves pain and function, but its effect is less than PRP. Corticosteroids offer temporary relief, but with risks of side effects. The combination of PRP and HA shows superior benefits. Mesenchymal stem cells (MSC) promise regenerative effects, but require further studies to confirm their long-term safety and efficacy. Discussion: Intra-articular therapies are a key alternative for patients with trauma pathologies seeking non-surgical options. Although PRP emerges as the most promising treatment, variability in methods and populations studied limits the generalizability of findings. Furthermore, combining therapies might offer a new avenue of management but requires further robust research. Conclusions: PRP stands out as the most effective therapy for pain relief and joint function improvement in trauma pathologies, outperforming HA and corticosteroids. Combinations such as PRP + HA are promising, while mesenchymal stem cells offer an innovative option for the future. However, further studies are needed to confirm these results and ensure long-term safety.