APLICACIÓN DE LA PROTEÓMICA EN EL DIAGNÓSTICO DE CÁNCER DE MAMA: AVANCES Y LIMITACIONES

Abstract

Introduction. Breast cancer is an extremely complex and heterogeneous disease that is characterized by uncontrolled growth of cells belonging to the breast tissue. It is essential to identify more sensitive biomarkers. A recent response has been the use of proteomics technology, which has provided excellent help in the characterization of new molecular biomarkers by measuring protein profiles. Objetive. Analyze the application of proteomics in the diagnosis of breast cancer, its Advances and Limitations. Methodology. To prepare the article, a bibliographic review was used based on research in highly relevant scientific journals, repositories and health databases such as Scopus, Embase, Science Direct, ProQuest, PubMed, Scielo, Medline. Results. The reviewed documents provide information about the application of different proteomic techniques in the diagnosis of breast cancer, many of their advances, but also the limitations that arise throughout this study. Many of the laboratory tests that can be performed for the diagnosis and management of breast cancer are highlighted. Conclusion. The application of proteomics in the diagnosis of breast cancer has represented a promising advance towards the early and personalized detection of this disease.