Carrera Ingeniería Bioquímica
Permanent URI for this collectionhttp://repositorio.uta.edu.ec/handle/123456789/809
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Item Actividad antioxidante y citotóxica in vitro de Valeriana decussata y Valeriana rígida en células cancerígenas(Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos y Biotecnología. Carrera de Ingeniería Bioquímica, 2021-03) Guacales Reinosa, Danny Alexander; Carrero Castillo, Yenddy Nayghit; Vargas López, José HomeroCancer represents a health problem worldwide, leaving with its high death rates that continue to rise. The treatments used to counteract the disease have high costs and are losing their effectiveness as cancer cells become increasingly resistant; hence the importance of looking for new therapeutic alternatives, in order to reestablish a new panorama in favor of the search for new phytocomposites extracted from plants, such as valerian species, characterized by its composition of terpenes, valeric acid, valtrates and essential oils with various anti-inflammatory, anticonvulsant and anti-tumor properties. The objective of the present investigation was the determination of the antioxidant and cytotoxic activity in vitro of extracts obtained from Valerian decussata and Valerian rigid in the breast cancer cell line (MCF-7). For this, cell viability studies were carried out using the MTT method, immunohistochemical tests, nitric oxide determination using the Griess method and the antioxidant activity with the TROLOX test. The presence of antioxidants and compounds with biological activity that acted were evidenced. beneficially over the MCF-7 cell line type.