Carrera Ingeniería Bioquímica

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Author: search.filters.author.Ortiz Pérez, Tatiana AnabelSubject: search.filters.subject.ACTIVIDAD CITOTÓXICA

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    Evaluación de la actividad antioxidante, antiinflamatoria y citotóxica in vitro de diferentes extractos de Chuquiragua (Chuquiragua jussieui) obtenidos mediante secado por aspersión
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos. Carrera de Ingeniería Bioquímica, 2017-03) Ortiz Pérez, Tatiana Anabel; Pérez Betancourt, Yunys
    The unsuitable used the medicinal plants in Ecuador the search new alternatives for reducing these problems such as get active compounds through technical process and the use endemic plants of Ecuador. The aim of present investigation was to evaluate active compounds showed in the vegetal extracts of Chuquiragua of different in vitro biological activities. The extract got the leaves and flowers through a maceration process with different solvents such as: distillated water and ethanol. Through the spray drying method got a compact powder of different extracts. The biological activities evaluate through in vitro method, the anti-inflammatory activity there were used erythrocytes healthy patients review the stability membrane of giving extract avoid to start inflammatory process. The cytotoxic activity was quantified through a colorimetric method of de bromide de 3-(4,5-dimetiltiazol-2-ilo)-2,5-difeniltetrazol (MTT) with cellular lineal of breast cancer MFC-7, and serial dilutions. In anti-inflammatory, antioxidant and cytotoxic activities, the aqueous ethanol leaves dried of sun was the best treatment with these results 92,602% of the protection, 147409,481 μg Gallic acid/g sample and 98,913% of inhibition cellular respectively. In conclusion, flowers and leaves of Chuquiragua showed biological activities that through pharmacological processes might to active compounds. These maybe use in medical ambit.