Carrera Ingeniería Bioquímica

Permanent URI for this collectionhttp://repositorio.uta.edu.ec/handle/123456789/809

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Subject: search.filters.subject.GESTIÓN DE CALIDAD

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Now showing 1 - 7 of 7
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    Evaluación de la calidad de un gel antibacterial elaborado a partir de Alcohol Artesanal con hidrolato de manzanilla (Matricaria chamomilla) y aceite esencial de naranja (Citrus spp.)
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos y Biotecnología. Carrera de Ingeniería Bioquímica, 2022-03) Merino Castillo, Erick Andrés; Robalino Martínez, Dolores del Rocío
    The antibacterial gel has become a complementary product for hand hygiene, preventing infections and the spread of diseases. This research proposes the evaluation of the quality of an antibacterial gel made from artisanal alcohol with chamomile hydrolate (Matricaria chamomilla) and essential oil of orange (Citrus spp. ), the physicochemical properties of the gel were identified, in which a pH value between 5.72 and 6.05 was obtained; a density of 0.876 to 0.885 grams over cubic centimeters and a viscosity of 7320 to 7956 Cps, these being the optimum values for this type of antibacterial cosmetics, complying with the external instructions for low-risk cosmetic products, belonging to the national agency of regulation, control and sanitary surveillance ARCSA. The quantification of the alcohol concentration in the antibacterial gel was performed by gas chromatography, complying with the provisions of the ARCSA in its resolution DE-015-2020 where the alcohol concentration was found in the range between sixty and seventy percent performing its antibacterial characteristics. The bacterial effectiveness tests were carried out according to the European standard UNE-EN-1040, applying the microbiological techniques of cosmetic products, where two strains of microorganisms Escherichia coli and Staphylococcus aureus were used, these tests were evaluated by means of a logarithmic scale, determining a high bactericidal activity for its antibacterial characteristics against the microorganisms evaluated, being this product ideal for hand disinfection since it complies with all the quality parameters.
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    Validación del método para determinación de detergentes en muestras de agua por espectrofotometría UV-Vis en el laboratorio AqLab de la ciudad del Coca
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos y Biotecnología. Carrera de Ingeniería Bioquímica, 2022-03) Aguirre Tubón, Ana Belén; Pérez Aldas, Lander Vinicio
    The validation of the method for determination of surfactants in water samples by UV-vis spectrophotometry was carried out in the environmental analysis and evaluation laboratory Aqlab in the city of Coca. Its validation was carried out taking into account the analytical need of the laboratory, validation parameters of the INEN ISO IEC 17025 standard and SAE regulations, environmental regulations described in the TULSMA, in its Environmental Quality and Effluent Discharge Standard: Water Resource and the Municipal Ordinances of the Orellana Canton. The method 5540 C corresponding to the determination of anionic surfactants as MBAS described in the Standard Methods was used for the matrices of water for human consumption, natural water and waste water. The validation objectives were established and the corresponding experimental design was proposed under conditions of repeatability and reproducibility. The following parameters were analyzed: Response Function, Limit of detection, Limit of quantification, Precision (repeatability and reproducibility), Veracity, Uncertainty and Working Interval of the method. Through the statistical analysis of data, it was demonstrated that the method is suitable for the intended application, by meeting the validation objectives set for a CVr and CVR less than 30 percent for accuracy, a recovery percentage of 80 to 120 percent for veracity, an uncertainty U less than 30 percent with a 95 percent confidence interval (k is 2) and a method working range comprising concentration levels 0,10 to 8,85 ppm MBAS.
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    Diseño de un manual de buenas prácticas de manufactura para la empresa Laboratorio Génesis ubicada en la provincia de Tungurahua en la ciudad de Ambato
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos y Biotecnología. Carrera de Ingeniería Bioquímica, 2021-09) Villacís Arcos, Ana Gabriela; Pérez Aldas, Lander Vinicio
    The main objective of this work is the development of a manual of Good Manufacturing Practices (GMP) for the company Génesis Laboratory LABGENESIS CIA. LTDA. For its effect, a diagnosis of the initial situation of the company was carried out, having an average compliance of 48 percent, a value that indicates that the company requires an intervention to improve certain aspects of non-compliance. Once the inconsistencies were determined, an improvement plan was developed to develop them in the company, thus the execution of the changes was carried out generating an increase of 40 percent of compliance with the GMP regulations for pharmaceutical laboratories of medicines in general. Finally, the improvements achieved were evaluated, resulting in a final total compliance of 88 percent, which highlights that the work carried out was assertive in the aspects of greatest deficiency found in accordance with the GMP regulation.
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    Calificación de diseño, instalación, operación y desempeño del sistema de generación, almacenamiento y distribución de aire comprimido en el laboratorio Neorfármaco del Ecuador Neorfármaco Cía. Ltda.
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos y Biotecnología. Carrera de Ingeniería Bioquímica, 2021-03) Barros Villacrés, Leslie Melanie; Arancibia Soria, Mirari Yosune
    In this study the compressed the qualification of the compressed air system was carried out from its generation, storage and distribution in the Neorfármaco Laboratory in Ambato city. Air system was qualified starting from its generation, storage and distribution in the Neofármaco Laboratory. Compressed air is widely used in various drug production processes. Impurities in compressed air may jeopardize products. Therefore, it is mandatory to satisfy the quality criteria that govern this type of critical support systems. For the qualification, the protocols and reports of design qualification (DQ), installation qualification (IQ), operation qualification (OQ) and performance qualification (PQ) were implemented. For DQ protocols, it was supports that the design satisfies the user requirements, in the same way the IQ was verified the physical conditions of the air, characteristics and components of the system. In the operation qualification, the correct operation of the system was verified and the results of the operational tests show that the compressed air system accomplish the quality attributes as established the ISPE and ISO 8573 standards, Thus, class 2 in particle content, class 4 for dew point and class 2 for oil content and without the presence of microbial growth. Finally, in the performance qualification, the same parameters were evaluated for 3 days, showing that the system is continuous, reproducible and distributes quality compressed air.
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    Implementación del Sistema de gestión de calidad bajo norma NTE INEN-ISO/IEC 17025:2006 para la optimización de procesos en Ecuachemlab Cía. Ltda., laboratorio químico y microbiológico del Ecuador.
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos. Carrera de Ingeniería Bioquímica, 2016-07) Zamora Ortiz, Lizeth Viviana; Córdova Suárez, Manolo Alexander
    In a competitive market a global scale. It offers a permanent quality in every product and service. It is essential to have a quality management system that can satisfy the demands of consumers for processes performed in ECUACHEMLAB Cía. Ltda. with the implementation of NTE INEN ISO / IEC 17025. 2006; that allows to establish their ability to compete as a chemical laboratory and microbiologist, which can provide customers with a guarantee that their product went through reliable tests, thus ensuring reliability of these. The Quality Management System was implemented according with the requirements established in NTE INEN ISO / IEC 17025, for the standardization of processes. 10% was satisfactory, but 90% are not adequately fulfilled. However they did related activities with the job and there was documentation or fulfill, with the generation of necessary documentation such as Quality Manual, procedures, records and other documents for application in Ecuachemlab Cia. Ltda. The system Quality Management was implemented, maintaining order, control and uniformity in all processes and possible actions to take in case of raising singularities in the development of activities and finally the compliance of the QMS was verified through an internal audit, which found that 96% of criteria meet the requirements of SAE, while 3% of the criteria are documented defined but have not been implemented efficiently, and only 1% have activities that allow resolve even if not documented in any way, thus demonstrating the high performance of the QMS.
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    Implementación del Parámetro de Dióxido de azufre (SO2) bajo el Método US. EPA.: Parte 60; Apéndice A - Método 6C, en el Sistema de Calidad del Laboratorio AMBI FOR HEALTH SERVICES CÍA. LTDA.
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos. Carrera de Ingeniería Bioquímica, 2016-03) Acosta Villacís, Álvaro Gabriel; Valencia Silva, Alex Fabián
    Validation is the process established to obtain and documented evidence demonstrating a method of analysis, enough to generate reliable and reproducible results expected within defined ranges work well; It provides a high degree of confidence and assurance of the analytical method and is performed compulsorily when developing a new procedure, ensuring that the proposed method meets the desired results. It should be noted that the methods described in standards or official texts are considered validated, although they refer only to general methods. To perform the validation of the method for determining SO2, the methodology described in US.EPA applied. 6C method, supplemented by an instrumental analyzer which employs detection principle Pulsed Fluorescence method and reliability was checked by evaluation of parameters such as; precision, accuracy, linearity and specificity. Also included, the determination of measurement uncertainty and the working range for this method. The results of the working ranges were: low range (LR); working limits from 1 ppm to 150 ppm of SO2, with 6.27% uncertainty, coefficients repeatability CVr = 0.68 and reproducibility CVR = 2.59 less than 5%. The medium range (MR) with limits from 150 ppm to 300 ppm of SO2 with uncertainty of 2.90% and coefficients of variation for repeatability CVr = 0.34 and reproducibility CVR= 0.56 less than 1%. While senior (HR) whose job level is from 304.6 ppm to 1029 ppm of SO2 introduced an uncertainty of 2.59% and coefficients of variation for repeatability and lower reproducibility 1% respectively, CVr = 0.075% and CVR = 0.37% .
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    Implementación de un Método colorimétrico para el Control de calidad de tintes capilares producidos en los Laboratorios René Chardon del Ecuador.
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos. Carrera de Ingeniería Bioquímica, 2016-01) Murillo Carrasco, Andrea Carolina; Pérez Aldas, Lander Vinicio
    The hair color industries of the world have been implementing instrumental methods that allowed the quantification of the exact color tones in hair colors, expressing them in numerical relation; allowing to establish quality parameters that can guaranty the correct tone between batches. The method used by the René Chardon of Ecuador actually consists on an empirical release mechanism assessed by visual perception, which varies, as the results are limited to the expertise of the analyst, in addition it cannot be quantifiable, reason why there is no follow up on the tonality. The trust on the brand and the results that the client hope for it is going to lose value, as soon as the client notices the deviations of the tone of the color on the final product. The research evaluates two colorimetric methods to determine numerically the tones of the capillary colors. The former method is based on the extraction of the capillary pigments that are expressed on wicks of hair with related solvents, determining that the best treatment for the extraction of capillary colors, is based on the extraction with methanol using agitation on an ultrasonic bath during two hours. The second method proposed uses HunterLab MiniScan EZ colorimeter that provides colorimetric coordinates, the different mathematical combinations distinguish minimal differences in color between batches. The lightness (L*), the tone (h*), the chrome (C*), and the global difference of color (ΔE), were studied using batches of analogs capillary colors, specifically Borgoña (code 4.5), light brown (code 5.0) violet golden cinnamon (code 5.35); made in different periods of the present year. From this comparison, the operative procedure (IO.251.2.36) was done, and this methodology was apply to the control quality system for the production of hair color. Considering as a criteria of acceptance a coefficient of variation lower than 5%.